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Differential roles of stromal cells, interleukin-7, and kit-ligand in the
regulation of B lymphopoiesis
LG Billips, D Petitte, K Dorshkind, R Narayanan, CP Chiu and KS Landreth
Mary Babb Randolph Cancer Center, West Virginia University Health Sciences
Center, Morgantown 26506.
Newly formed B lymphocytes are a population of rapidly renewed cells in the
bone marrow of mammals and their steady state production presumably depends
on a cascade of regulatory cells and cytokines. Although considerable
information has been forthcoming about the role of interleukin-7 (IL-7) in
potentiating pre-B-cell proliferation, few studies have addressed the
possibility that multiple cytokines are involved in the progression of
early events in cellular differentiation and proliferation in this
hematopoietic lineage. Our laboratory previously described pre-B-cell
differentiation mediated by the bone marrow stromal cell line S17. In this
study, we further delineate the role of stromal cells in differentiation
and proliferation of pre-B cells. These experiments show that the stromal
cell line S17 potentiates the proliferative effect of IL-7 on B-lineage
cells and that this S17-derived potentiator can be replaced with
recombinant kit- ligand (KL). Our results further show that pre-B-cell
formation from B220-, Ig- progenitor cells and expression of mu heavy chain
of immunoglobulin is uniquely dependent on the presence of S17 stromal
cells and cannot be reproduced with IL-7, KL, or costimulation with both
IL-7 and KL. These data contribute to a rapidly evolving model of stromal
cell regulation of B-cell production in the marrow and suggest unique roles
for IL-7, KL, and as yet uncharacterized stromal cell- derived lymphokines
in this process.
Volume 79,
Issue 5,
pp. 1185-1192,
03/01/1992
Copyright © 1992 by The American Society of Hematology
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