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Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia

D Claxton, A Deisseroth, M Talpaz, C Reading, H Kantarjian, J Trujillo, S Stass, G Gooch and G Spitzer

University of Texas M.D. Anderson Cancer Center, Department of Hematology, Houston 77030.

Interferon (IFN) therapy of early chronic myelogenous leukemia (CML) frequently produces partial or complete cytogenetic remission of the disease. Patients with complete cytogenetic remission often continue on therapy for several years with bone marrow showing only diploid (normal) metaphases. We studied hematopoiesis in five female patients with major cytogenetic remissions from CML during IFN therapy. Clonality analysis using the BstXI PGK gene polymorphism showed that granulocytes were nonclonal in all patients during cytogenetic remission. BCR region studies showed rearrangement only in the one patient whose remission was incomplete at the time of sampling. Granulopoiesis is nonclonal in IFN-induced remissions of CML and may be derived from normal hematopoietic stem cells.

Volume 79, Issue 4, pp. 997-1002, 02/15/1992
Copyright © 1992 by The American Society of Hematology


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  Copyright © 1992 by American Society of Hematology         Online ISSN: 1528-0020