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The c-kit receptor ligand functions as a mast cell chemoattractant
CJ Meininger, H Yano, R Rottapel, A Bernstein, KM Zsebo and BR Zetter
Department of Surgery, Harvard Medical School, Children's Hospital, Boston,
MA 02115.
Mast cells accumulate at sites of neovascularization, solid tumors, and
many immune reactions. Such accumulation requires directed migration of
mature mast cells or their precursors. The nature of the chemoattractants
that regulate mast cell motility and the identity of the receptors that
mediate the chemotactic response are poorly understood. We have tested the
ability of stem cell factor (SCF), a mast cell growth factor, to stimulate
mast cell migration. Our results show that SCF is a potent mast cell
attractant that stimulates directional motility of both mucosal and
connective tissue-type mast cells. The activity is potentiated by
costimulation with interleukin-3 (IL-3), another mast cell chemoattractant.
SCF, a known ligand for the c-kit tyrosine kinase receptor, was unable to
stimulate motility in W42 mutant mast cells, which have a defective c-kit
tyrosine kinase. However, W42 mast cells were still able to migrate in
response to IL-3. These results show that SCF is a chemotactic factor as
well as a growth factor and that the c-kit receptor can transduce signals
leading to both cell proliferation and increased directional cell motility.
Volume 79,
Issue 4,
pp. 958-963,
02/15/1992
Copyright © 1992 by The American Society of Hematology
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