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Correlation of cytogenetic patterns and clinicobiological features in adult
acute myeloid leukemia expressing lymphoid markers [see comments]
A Cuneo, JL Michaux, A Ferrant, L Van Hove, A Bosly, M Stul, P Dal Cin, E Vandenberghe, JJ Cassiman and M Negrini
Institute of Hematology, University of Ferrara, Italy.
Cytogenetic, biomolecular, and clinicopathologic features were
retrospectively studied in 34 adult patients with acute myelogenous
leukemia expressing one or more of the following lymphoid-associated
markers (LMs): CD7, CD2, CD10, CD19, CD22, TdT. Six patients showed 11q23
rearrangements (group I); three patients had the classic Ph chromosome
(group II); 15 patients had aberrations of the myeloid type (group III),
including four patients with structural aberrations of 13q or trisomy 13,
three patients with 7q and 1q anomalies, and two patients with trisomy 11q.
Ten patients had a normal karyotype (group IV). Anomalies exclusively
associated with lymphoid malignancies were not seen. Ig H and/or T-cell
receptor genes were found to be rearranged in 50% and 66% of patients in
cytogenetic groups I and II, respectively, versus 8% in group III and 12%
in group IV. Likewise, more than one LM was more frequently detected in
groups I and II. In group III, two of four patients with aberrations of
chromosome 13 expressed two or more lymphoid features. Clinically, patients
belonging to cytogenetic groups I and II were generally young, presented
with a high white blood cell (WBC) count, and had a low complete remission
rate. Survival in Ph chromosome-positive cases was uniformly short. We
conclude that although there is no cytogenetic anomaly specifically
associated with acute myelogenous leukemia expressing LM, a Morphologic,
Immunologic, and Cytogenetic classification may constitute a working basis
for further studies aimed at a better definition of clinicopathologic
features and optimal treatment strategies for these leukemias.
Volume 79,
Issue 3,
pp. 720-727,
02/01/1992
Copyright © 1992 by The American Society of Hematology
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