|
|
 Previous Article | Table of Contents | Next Article 
Blood flow to bone marrow during development of anemia or polycythemia in
the rat
PO Iversen, G Nicolaysen and HB Benestad
Department of Physiology, University of Oslo, Norway.
We applied the radioactive microsphere method to follow the magnitude and
time course (0 to 96 hours) of blood flow changes during development and
recovery from anemia in awake rats. Blood flow was also monitored during a
96-hour period after polycythemia was induced (erythropoietin administered
subcutaneously [SC]). The possible influence of innervation was also
examined. After a blood loss of approximately 50% (hypovolemia), blood flow
to the femoral marrow tripled within 12 hours and remained elevated for the
entire 96-hour period. The relative increase in blood flow to the femoral
bone was even greater. Similar findings were obtained in rats with
phenylhydrazine (PHZ) hemolytic anemia (normovolemia). Denervation had no
detectable effect on the increased blood flow to either marrow or bone. The
augmented blood flow during hemolytic anemia was accompanied by a doubling
of the oxygen consumption rate by the marrow, while the glucose uptake was
not detectably altered. Erythropoietin supplements (3 x 1,000 IU/kg, SC,
6-hour intervals) increased blood flow to the marrow by approximately 25%
after 48 hours, and at 72 hours the blood flow had reached a value twice
that obtained under control conditions. These results indicate that blood
flow to bone marrow is highly variable and hormonally and/or locally
regulated. This may have practical consequences for marrow transplantation
technology and for administration of drug therapy to patients with
insufficient bone marrow hematopoiesis.
Volume 79,
Issue 3,
pp. 594-601,
02/01/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
H. Wiig, E. Berggreen, B. A. S. Borge, and P. O. Iversen
Demonstration of altered signaling responses in bone marrow extracellular fluid during increased hematopoiesis in rats using a centrifugation method
Am J Physiol Heart Circ Physiol,
May 1, 2004;
286(5):
H2028 - H2034.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. O. Iversen, C. A. Drevon, and J. E. Reseland
Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis
Blood,
December 1, 2002;
100(12):
4123 - 4128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Sorensen, T.-A. Read, T. Porwol, B. R. Olsen, R. Timpl, T. Sasaki, P. O. Iversen, H. B. Benestad, B. K. L. Sim, and R. Bjerkvig
Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma
Neuro-oncol,
January 1, 2002;
4(1):
1 - 8.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. O. Iversen, E. Berggreen, G. Nicolaysen, and K. Heyeraas
Regulation of extracellular volume and interstitial fluid pressure in rat bone marrow
Am J Physiol Heart Circ Physiol,
April 1, 2001;
280(4):
H1807 - H1813.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.A. Miyan, C.S. Broome, A.D. Whetton;, H.B. Benestad, P.O. Iversen, and A. Nja
Neural Regulation of Bone Marrow
Blood,
October 15, 1998;
92(8):
2971 - 2972.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. B. Benestad, I. Strom-Gundersen, P. Ole Iversen, E. Haug, and A. Nja
No Neuronal Regulation of Murine Bone Marrow Function
Blood,
February 15, 1998;
91(4):
1280 - 1287.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
