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Mutations of the p53 gene in adult T-cell leukemia
A Sakashita, T Hattori, CW Miller, H Suzushima, N Asou, K Takatsuki and HP Koeffler
Department of Medicine, Cedars-Sinai Medical Center, UCLA School of
Medicine 90024-1678.
The p53 tumor suppressor gene was examined by direct sequencing of
polymerase chain reaction-amplified DNA from fresh tumor cells of 10
patients with adult T-cell leukemia (ATL). Samples included nine patients
with acute or lymphomatous ATL, and one patient in whom samples were
examined in both his acute and chronic stages of ATL. Four missense
mutations and one silent point mutation in the coding region of the p53
gene were found in cells from five patients with either acute or
lymphomatous ATL. The missense mutations were homozygous and occurred in
evolutionarily highly conserved regions of p53. One patient had no p53
mutation in his leukemic cells during chronic phase of ATL, but had a
homozygous point mutation at codon 273 (Arg to His) when he progressed to
acute ATL. In summary, we show that p53 is frequently mutated in the acute
phase of ATL and one informative case suggests that p53 mutations may be
associated with the transition from chronic to acute ATL.
Volume 79,
Issue 2,
pp. 477-480,
01/15/1992
Copyright © 1992 by The American Society of Hematology
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