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Macrophage differentiation-specific expression of NF-IL6, a transcription
factor for interleukin-6
S Natsuka, S Akira, Y Nishio, S Hashimoto, T Sugita, H Isshiki and T Kishimoto
Institute for Molecular and Cellular Biology, Osaka University, Japan.
NF-IL6 was originally identified as a DNA binding protein regulating
interleukin-1 (IL-1)-stimulated IL-6 expression. Direct cloning of NF- IL6
showed its homology with C/EBP, a hepatocyte- and adipocyte- specific
transcription factor. This study showed that the expression of NF-IL6
messenger RNA (mRNA) increased markedly during the differentiation to a
(mRNA) increased markedly during the differentiation to a macrophage
lineage in mouse myeloid leukemia cells M1, human histiocytic leukemia
cells U937, promyelocytic leukemia cells HL-60, and human peripheral
monocytes. Particularly in HL-60 cells that undergo granulocyte or
macrophage differentiation depending on inducers, NF-IL6 mRNA was
specifically upregulated during macrophage differentiation but not
granulocyte differentiation. It was also shown that the functional NF-IL6
protein increased during the differentiation of U937 cells. Furthermore,
recombinant NF-IL6 was found to bind to the regulatory regions of the IL-1,
tumor necrosis factor, granulocyte colony-stimulating factor, and lysozyme
genes, which are expressed in mature macrophages. These results suggest
that NF-IL6 may possibly be involved as an important transcription factor
in the process of activation and/or differentiation of macrophages.
Volume 79,
Issue 2,
pp. 460-466,
01/15/1992
Copyright © 1992 by The American Society of Hematology
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