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Regulation of B-cell growth and immunoglobulin gene transcription by
interleukin-6
JE Tanner and G Tosato
Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD.
Interleukin-6 (IL-6) stimulates growth and immunoglobulin (lg) secretion in
Epstein-Barr virus (EBV)-infected B cells. In this study, we demonstrate
that B-cell activation by IL-6 is associated with an initial induction of
c-myc, a gene believed to act as a competence factor for increased RNA
transcription and DNA replication, and by increases in DNA, RNA, and
protein synthesis, as well as cell number. IL-6 increased the levels of lg
mRNA per cell in comparison to a non- cycle-dependent cellular mRNA,
tubulin. However, two other cell cycle- dependent cellular mRNAs, c-myc and
actin, were also induced by IL-6 comparable to lg mRNAs. Increased levels
of lg mRNA were not due to significant changes in RNA turnover, but
appeared to reflect increased levels of RNA transcription. Together, these
findings support the notion that IL-6 plays an important role as a
stimulator of DNA and RNA synthesis in EBV-activated B cells.
Volume 79,
Issue 2,
pp. 452-459,
01/15/1992
Copyright © 1992 by The American Society of Hematology
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