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Expression of activin A/erythroid differentiation factor in murine bone
marrow stromal cells
T Yamashita, S Takahashi and E Ogata
Department of Internal Medicine, Faculty of Medicine, University of Tokyo,
Japan.
Accumulating evidence suggests that activin A/erythroid differentiation
factor (EDF), a homodimer of beta A chain, is a physiologic hematopoietic
factor, particularly of erythroid lineage. Media conditioned by phorbol
myristate acetate (PMA)-stimulated murine bone marrow stromal cell lines,
MC3T3-G2/PA6 and ST2, contained activin A/EDF, assayed as the activity
inducing erythroid differentiation of an activin A/EDF-responsive murine
erythroleukemia cell clone F5. Follistatin, a protein specifically binding
to activin A/EDF, abolished this erythroid differentiation. Northern blot
analysis showed that PMA rapidly increased beta A chain messenger RNA
levels in MC3T3-G2/PA6 and ST2 cells. In a search for natural stimulators,
we found that tumor necrosis factor-alpha, in itself and synergistically
with interleukin-1 beta, induced activin A/EDF production in both cell
lines. These results indicate that stromal cells produce activin A/EDF in
bone marrow.
Volume 79,
Issue 2,
pp. 304-307,
01/15/1992
Copyright © 1992 by The American Society of Hematology
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