|
|
 Previous Article | Table of Contents | Next Article 
CD16- CD56+ natural killer cells after bone marrow transplantation
R Jacobs, M Stoll, G Stratmann, R Leo, H Link and RE Schmidt
Abt. fur Klinische Immunologie und Transfusionsmedizin, Medizinische
Hochschule Hannover, Germany.
Natural killer (NK) cells are phenotypically defined as lymphocytes
expressing the antigens CD56 and mostly CD16 (Fc gamma RIII), but lacking
CD3. A small CD3- CD16- CD56+ NK cell subset has been described in normal
individuals representing less than 2% of peripheral blood lymphocytes. We
analyzed here 70 patients for their reconstitution of the immune system
during follow-up after autologous or allogeneic bone marrow
transplantation. In 35% of these patients, two different NK cell subsets,
namely CD56+dim and CD56+bright cells, were observed. The mean duration of
these two subsets after transplant was 4 months. Sixty-five percent of the
patients exhibited an increased number of NK cells, but only the typical
CD16+ CD56+dim population. The CD56+bright subpopulation represented a
particular CD3- CD16- NK subset, with posttransplant frequencies up to 70%
of all NK cells and 40% of peripheral blood lymphocytes, respectively. In
contrast to normal CD56+dim NK cells, CD56+bright cells coexpressed the
activation antigens p75 beta-chain of interleukin-2 receptor (IL-2R), CD2R,
and CD26, but were negative for CD16. NK and antibody-dependent cellular
cytotoxicity activity of CD56+bright cells was low compared with CD56+dim
NK cells. But using IL-2 and interferon gamma, their cytotoxicity could be
enhanced even more than in CD56+dim lymphocytes. These different subsets
may reflect distinct activation or differentiation steps of NK cells during
reconstitution of the immune system. Their differential response to IL-2
may be of functional importance for posttransplant cytokine therapy.
Volume 79,
Issue 12,
pp. 3239-3244,
06/15/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
N. D. Huntington, N. Legrand, N. L. Alves, B. Jaron, K. Weijer, A. Plet, E. Corcuff, E. Mortier, Y. Jacques, H. Spits, et al.
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
J. Exp. Med.,
December 22, 2008;
(2008)
jem.20082013.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Nave, G. Mueller, B. Siegmund, R. Jacobs, T. Stroh, U. Schueler, M. Hopfe, P. Behrendt, T. Buchenauer, R. Pabst, et al.
Resistance of Janus Kinase-2 Dependent Leptin Signaling in Natural Killer (NK) Cells: A Novel Mechanism of NK Cell Dysfunction in Diet-Induced Obesity
Endocrinology,
July 1, 2008;
149(7):
3370 - 3378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Wang, B. Grzywacz, D. Sukovich, V. McCullar, Q. Cao, A. B. Lee, B. R. Blazar, D. N. Cornfield, J. S. Miller, and M. R. Verneris
The unexpected effect of cyclosporin A on CD56+CD16 and CD56+CD16+ natural killer cell subpopulations
Blood,
September 1, 2007;
110(5):
1530 - 1539.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Wendt, E. Wilk, S. Buyny, J. Buer, R. E. Schmidt, and R. Jacobs
Gene and protein characteristics reflect functional diversity of CD56dim and CD56bright NK cells
J. Leukoc. Biol.,
December 1, 2006;
80(6):
1529 - 1541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. W. Timmons, M. A. Tarnopolsky, and O. Bar-Or
Sex-based effects on the distribution of NK cell subsets in response to exercise and carbohydrate intake in adolescents
J Appl Physiol,
May 1, 2006;
100(5):
1513 - 1519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. S. Woll, C. H. Martin, J. S. Miller, and D. S. Kaufman
Human Embryonic Stem Cell-Derived NK Cells Acquire Functional Receptors and Cytolytic Activity
J. Immunol.,
October 15, 2005;
175(8):
5095 - 5103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nguyen, N. Dhedin, J.-P. Vernant, M. Kuentz, A. A. Jijakli, N. Rouas-Freiss, E. D. Carosella, A. Boudifa, P. Debre, and V. Vieillard
NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect
Blood,
May 15, 2005;
105(10):
4135 - 4142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Chklovskaia, P. Nowbakht, C. Nissen, A. Gratwohl, M. Bargetzi, and A. Wodnar-Filipowicz
Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: effects of endogenous flt3 ligand
Blood,
May 15, 2004;
103(10):
3860 - 3868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Barao, D. Hudig, and J. L. Ascensao
IL-15-Mediated Induction of LFA-1 Is a Late Step Required for Cytotoxic Differentiation of Human NK Cells from CD34+Lin- Bone Marrow Cells
J. Immunol.,
July 15, 2003;
171(2):
683 - 690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Jacobs, C. R. Pawlak, E. Mikeska, D. Meyer-Olson, M. Martin, C. J. Heijnen, M. Schedlowski, and R. E. Schmidt
Systemic lupus erythematosus and rheumatoid arthritis patients differ from healthy controls in their cytokine pattern after stress exposure
Rheumatology,
August 1, 2001;
40(8):
868 - 875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Tiberghien, C. Ferrand, B. Lioure, N. Milpied, R. Angonin, E. Deconinck, J.-M. Certoux, E. Robinet, P. Saas, B. Petracca, et al.
Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft
Blood,
January 1, 2001;
97(1):
63 - 72.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
