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Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue
G Niedobitek, H Herbst, LS Young, L Brooks, MG Masucci, J Crocker, AB Rickinson and H Stein
Institute of Pathology, Klinikum Steglitz, Free University of Berlin,
Germany.
Taking advantage of the abundant expression of the small Epstein-Barr virus
(EBV)-encoded RNAs (EBERs) in latently infected cells, we have analyzed 72
normal and hyperplastic lymph nodes and three tonsils of acute infectious
mononucleosis (IM) for the presence and distribution of EBV+ cells using
EBER-specific in situ hybridization, in some cases combined with
immunohistologic demonstration of cell type- characteristic antigens. In
IM, large numbers of EBV+ lymphoid B blasts were detectable in
extrafollicular areas, whereas germinal centers were generally free of EBV+
cells. In reactive lymph nodes, the frequency of EBV+ cells varied with the
degree of lymphoid hyperplasia and underlying immune status. The lowest
numbers of EBV+ cells were detected in nonactivated lymph nodes and highest
in human immunodeficiency virus-associated lymphadenopathy. If present in
these lymph nodes, EBV+ cells were almost exclusively localized to
extrafollicular areas, as also observed in IM. However, in contrast to IM,
these cells were mainly small lymphocytes. Furthermore, in some instances,
occasional scattered EBV+ cells were seen within germinal centers, and in
two cases diffuse expansions of EBV+ cells occurred within a single
germinal center each, indicating that under certain circumstances EBV+ B
lymphocytes may participate in physiologic germinal center reactions. These
findings reflect the interference of EBV with physiologic lymphoid
differentiation pathways and provide a link to EBV-associated malignant
lymphomas with a postulated origin from germinal center cells.
Volume 79,
Issue 10,
pp. 2520-2526,
05/15/1992
Copyright © 1992 by The American Society of Hematology
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