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Synergistic interactions between interleukin-11 and interleukin-4 in
support of proliferation of primitive hematopoietic progenitors of mice
M Musashi, SC Clark, T Sudo, DL Urdal and M Ogawa
Department of Medicine, Medical University of South Carolina, Charleston.
Interleukin-11 (IL-11) is a newly identified lymphohematopoietic cytokine
originally derived from the primate bone marrow stromal cell line, PU-34.
Separately, we reported that IL-11 augments IL-3-dependent proliferation of
primitive murine hematopoietic progenitors in culture. We have now examined
the synergistic interactions between IL-11 and IL- 4 in support of colony
formation from marrow cells of mice treated 2 days before with 150 mg/kg
5-fluorouracil. Neither recombinant human IL- 11 nor murine IL-4 alone was
effective in the support of colony formation. When the two factors were
combined, there was major enhancement of colony formation, including that
of multilineage colony- forming cells. Serial observations (mapping
studies) of development of multipotential blast cell colonies indicated
that the synergy between IL-11 and IL-4 is due in part to shortening of the
dormant period of the stem cells, an effect very similar to that of IL-6
and granulocyte colony-stimulating factor. The combination of IL-11 and
IL-4 may be useful in the stimulation of dormant hematopoietic stem cells
in vivo.
Volume 78,
Issue 6,
pp. 1448-1451,
09/15/1991
Copyright © 1991 by The American Society of Hematology
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