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Human herpesvirus-6 infection in bone marrow transplantation
T Yoshikawa, S Suga, Y Asano, T Nakashima, T Yazaki, R Sobue, M Hirano, M Fukuda, S Kojima and T Matsuyama
Department of Pediatrics, Fujita Health University School of Medicine,
Aichi, Japan.
Twenty-five pediatric patients who received bone marrow transplantation
(BMT) were studied prospectively to determine the relationship between BMT
and human herpesvirus-6 (HHV-6) infection by the virus isolation from
peripheral blood and/or bone marrow and by determining neutralizing
antibodies to HHV-6 during the 2 months following BMT. All of the 25 donors
and the recipients were immune to HHV-6 at the time of BMT and the virus
was not isolated from them. HHV-6 was isolated from peripheral blood and/or
bone marrow mononuclear cells in ten (40%) of the 25 recipients between day
14 and day 22 of BMT, but not from any other day. Two additional recipients
showed a significant increase in the antibody titer. Thus, infection with
HHV-6 was confirmed in 12 (48%) of the 25 recipients. Four of the 12
developed skin rashes; three of these four had a febrile episode when the
virus was isolated, whereas none of the remaining 13 developed the skin
rash. These results suggest a frequent infection with HHV-6 only a few
weeks after BMT and a close association between the infection with the
virus and the development of skin rashes.
Volume 78,
Issue 5,
pp. 1381-1384,
09/01/1991
Copyright © 1991 by The American Society of Hematology
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