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Interleukin-9 expression in human malignant lymphomas: unique association
with Hodgkin's disease and large cell anaplastic lymphoma
H Merz, FA Houssiau, K Orscheschek, JC Renauld, A Fliedner, M Herin, H Noel, M Kadin, HK Mueller-Hermelink and J Van Snick
Department of Pathology, University of Wurzburg, Germany.
To test the possibility that interleukin-9 (IL-9), the human homologue of
the mouse T-cell growth factor P40, may be involved in the pathogenesis of
human lymphomas, we examined IL-9 expression in a variety of tumors both by
Northern blot analysis and by in situ hybridization. Of 18 B-cell
non-Hodgkin's lymphomas and 11 peripheral T- cell lymphomas, none expressed
IL-9 message. By contrast, IL-9 message was found in two of six cases of
large cell anaplastic lymphoma (LCAL) and in 6 of 13 cases of Hodgkin's
disease (HD). In HD the strongest signals were observed in Hodgkin (H) and
Sternberg-Reed (SR) cells, but IL-9 mRNA was also detected in small
lymphocytic cells. A search for IL- 9 message in a panel of 20 cell lines
derived both from hematopoietic and nonhematopoietic tumors confirmed the
unique association of IL-9 expression with HD and LCAL in as much as the
only two cell lines with IL-9 message were derived from cases of HD and
LCAL. These results suggest that IL-9 is not involved as an autocrine
growth factor in the pathogenesis of most B- and T-cell lymphomas, but that
it may play a role in HD and LCAL.
Volume 78,
Issue 5,
pp. 1311-1317,
09/01/1991
Copyright © 1991 by The American Society of Hematology
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