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AW Jensen, M Hokland, H Jorgensen, J Justesen, J Ellegaard and P Hokland
University Department of Immunology, University of Aarhus, Denmark.
In a series of 100 acute myeloid leukemia (AML) patients defined by
cytochemistry and immunophenotyping, 20 expressed T-lymphocyte associated
antigens on the surface of their blasts. While 15 expressed two or more
T-cell antigens, five were found to express only CD7. All patients belonged
to the French-American-British type M4, and four were under the age of 40.
Despite intensive chemotherapy, four never obtained a complete remission
and the fifth died of relapse after an allogenic bone marrow
transplantation. While 12 randomly selected T- cell antigen negative AML
patients showed only few rearrangements in Ig- or T-cell receptor (TCR)
genes, such genetic alterations were demonstrated in four of five patients
for the TCR delta gene and in all patients for the TCR beta gene.
Interestingly, DNA fragments of similar size were demonstrated in three of
five patients for both the beta and delta genes. These data suggest that
the solitary presence of CD7 among T-cell antigens in otherwise clearcut
AML cases identifies a group of patients with similarities in antigen
receptor gene configuration as well as outcome.
This article has been cited by other articles:
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| Copyright © 1991 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
