|
|
 Previous Article | Table of Contents | Next Article 
The effects on hematopoiesis of recombinant stem cell factor (ligand for
c-kit) administered in vivo to mice either alone or in combination with
granulocyte colony-stimulating factor
G Molineux, A Migdalska, M Szmitkowski, K Zsebo and TM Dexter
Cancer Research Campaign Department of Experimental Haematology, Paterson
Institute for Cancer Research, Christie Hospital, Manchester, UK.
Stem cell factor (SCF) is the ligand for the receptor encoded by the c- kit
proto-oncogene. Mutations of either c-kit or the SCF gene are responsible
for the defects of W and SI mutant mice, which both suffer a macrocytic
anemia, the former associated with defective stem cells and the latter with
a defective hematopoietic microenvironment. PEGylated recombinant rat SCF
was administered to normal or splenectomized mice for up to 21 days. SCF
was found to be a modest stimulator of peripheral blood neutrophil numbers
in both groups of animals. The peak in neutrophil numbers was higher and
occurred earlier in splenectomized mice. Bone marrow and spleen cellularity
changed little during treatment but the content of interleukin-3-responsive
progenitor cells and spleen colony-forming cells (CFU-S) reached very high
levels, particularly in the spleen. Using recombinant human granulocyte
colony-stimulating factor (rhG-CSF), we have shown that SCF induces a
greater than additive increase in both blood neutrophils and blood-borne
CFU-S. This synergy was seen throughout the dose range and may indicate a
clinical role for SCF either alone or in augmenting the activity of G-CSF
upon blood neutrophils and transplantable stem cells.
Volume 78,
Issue 4,
pp. 961-966,
08/15/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. Stokman, J. C. Leemans, I. Stroo, I. Hoedemaeker, N. Claessen, G. J. D. Teske, J. J. Weening, and S. Florquin
Enhanced mobilization of bone marrow cells does not ameliorate renal fibrosis
Nephrol. Dial. Transplant.,
February 1, 2008;
23(2):
483 - 491.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Dawn, Y. Guo, A. Rezazadeh, Y. Huang, A. B. Stein, G. Hunt, S. Tiwari, J. Varma, Y. Gu, S. D. Prabhu, et al.
Postinfarct Cytokine Therapy Regenerates Cardiac Tissue and Improves Left Ventricular Function
Circ. Res.,
April 28, 2006;
98(8):
1098 - 1105.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kawada, S. Takizawa, T. Takanashi, Y. Morita, J. Fujita, K. Fukuda, S. Takagi, H. Okano, K. Ando, and T. Hotta
Administration of Hematopoietic Cytokines in the Subacute Phase After Cerebral Infarction Is Effective for Functional Recovery Facilitating Proliferation of Intrinsic Neural Stem/Progenitor Cells and Transition of Bone Marrow-Derived Neuronal Cells
Circulation,
February 7, 2006;
113(5):
701 - 710.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Stokman, J. C. Leemans, N. Claessen, J. J. Weening, and S. Florquin
Hematopoietic Stem Cell Mobilization Therapy Accelerates Recovery of Renal Function Independent of Stem Cell Contribution
J. Am. Soc. Nephrol.,
June 1, 2005;
16(6):
1684 - 1692.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Hess, K. D. Levac, F. N. Karanu, M. Rosu-Myles, M. J. White, L. Gallacher, B. Murdoch, M. Keeney, P. Ottowski, R. Foley, et al.
Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte colony-stimulating factor alone versus granulocyte colony-stimulating factor in combination with stem cell factor
Blood,
July 18, 2002;
100(3):
869 - 878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Morrison, D. Qian, L. Jerabek, B. A. Thiel, I.-K. Park, P. S. Ford, M. J. Kiel, N. J. Schork, I. L. Weissman, and M. F. Clarke
A Genetic Determinant That Specifically Regulates the Frequency of Hematopoietic Stem Cells
J. Immunol.,
January 15, 2002;
168(2):
635 - 642.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. B. Forlow, J. R. Schurr, J. K. Kolls, G. J. Bagby, P. O. Schwarzenberger, and K. Ley
Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice
Blood,
December 1, 2001;
98(12):
3309 - 3314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. F. Duarte and D. A. Frank
SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways
Blood,
November 15, 2000;
96(10):
3422 - 3430.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tagaya, T. Kunisada, H. Yamazaki, T. Yamane, T. Tokuhisa, E. F. Wagner, T. Sudo, L. D. Shultz, and S.-I. Hayashi
Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice
Blood,
June 1, 2000;
95(11):
3363 - 3370.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Liu, J. Poursine-Laurent, and D. C. Link
Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF
Blood,
May 15, 2000;
95(10):
3025 - 3031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Schwarzenberger, W. Huang, P. Ye, P. Oliver, M. Manuel, Z. Zhang, G. Bagby, S. Nelson, and J. K. Kolls
Requirement of Endogenous Stem Cell Factor and Granulocyte-Colony-Stimulating Factor for IL-17-Mediated Granulopoiesis
J. Immunol.,
May 1, 2000;
164(9):
4783 - 4789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Neipp, T. Zorina, M. A. Domenick, B. G. Exner, and S. T. Ildstad
Effect of FLT3 Ligand and Granulocyte Colony-Stimulating Factor on Expansion and Mobilization of Facilitating Cells and Hematopoietic Stem Cells in Mice: Kinetics and Repopulating Potential
Blood,
November 1, 1998;
92(9):
3177 - 3188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-Y. Zhang, T. A. Vik, J. W. Ryder, E. F. Srour, T. Jacks, K. Shannon, and D. Wade Clapp
Nf1 Regulates Hematopoietic Progenitor Cell Growth and Ras Signaling in Response to Multiple Cytokines
J. Exp. Med.,
June 1, 1998;
187(11):
1893 - 1902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Roeder, G. de Haan, C. Engel, W. Nijhof, B. Dontje, and M. Loeffler
Interactions of Erythropoietin, Granulocyte Colony-Stimulating Factor, Stem Cell Factor, and Interleukin-11 on Murine Hematopoiesis During Simultaneous Administration
Blood,
May 1, 1998;
91(9):
3222 - 3229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Lyman and S. E. W. Jacobsen
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
Blood,
February 15, 1998;
91(4):
1101 - 1134.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Jin, H. Asano, and C. Anthony Blau
Stimulating Cell Proliferation Through the Pharmacologic Activation of c-kit
Blood,
February 1, 1998;
91(3):
890 - 897.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. H. Nocka, B. A. Levine, J.-L. Ko, P. M. Burch, B. E. Landgraf, R. Segal, and R. Lobell
Increased Growth Promoting But Not Mast Cell Degranulation Potential of a Covalent Dimer of c-Kit Ligand
Blood,
November 15, 1997;
90(10):
3874 - 3883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ito, Y. Ueda, M. Kokubun, M. Urabe, T. Inaba, H. Mano, H. Hamada, T. Kitamura, H. Mizoguchi, T. Sakata, et al.
Development of a Novel Selective Amplifier Gene for Controllable Expansion of Transduced Hematopoietic Cells
Blood,
November 15, 1997;
90(10):
3884 - 3892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Fehniger, W. E. Carson, E. Mrozek, and M. A. Caligiuri
Stem Cell Factor Enhances Interleukin-2-Mediated Expansion of Murine Natural Killer Cells In Vivo
Blood,
November 1, 1997;
90(9):
3647 - 3653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.A. Glaspy, E.J. Shpall, C.F. LeMaistre, R.A. Briddell, D.M. Menchaca, S.A. Turner, M. Lill, L. Chap, R. Jones, M.D. Wiers, et al.
Peripheral Blood Progenitor Cell Mobilization Using Stem Cell Factor in Combination With Filgrastim in Breast Cancer Patients
Blood,
October 15, 1997;
90(8):
2939 - 2951.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. C. Broudy
Stem Cell Factor and Hematopoiesis
Blood,
August 15, 1997;
90(4):
1345 - 1364.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Molineux, C. McCrea, X. Q. Yan, P. Kerzic, and I. McNiece
Flt-3 Ligand Synergizes With Granulocyte Colony-Stimulating Factor to Increase Neutrophil Numbers and to Mobilize Peripheral Blood Stem Cells With Long-Term Repopulating Potential
Blood,
June 1, 1997;
89(11):
3998 - 4004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. H. Moskowitz, P. Stiff, M. S. Gordon, I. McNiece, A. D. Ho, J. J. Costa, E. R. Broun, R. A. Bayer, M. Wyres, J. Hill, et al.
Recombinant Methionyl Human Stem Cell Factor and Filgrastim for Peripheral Blood Progenitor Cell Mobilization and Transplantation in Non-Hodgkin's Lymphoma Patients --- Results of a Phase I/II Trial
Blood,
May 1, 1997;
89(9):
3136 - 3147.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Roberts, S. Foote, W. S. Alexander, C. Scott, L. Robb, and D. Metcalf
Genetic Influences Determining Progenitor Cell Mobilization and Leukocytosis Induced by Granulocyte Colony-Stimulating Factor
Blood,
April 15, 1997;
89(8):
2736 - 2744.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. van Os, D. Dawes, J. M.K. Mislow, A. Witsell, and P. M. Mauch
Host Conditioning With 5-Fluorouracil and kit-Ligand to Provide for Long-Term Bone Marrow Engraftment
Blood,
April 1, 1997;
89(7):
2376 - 2383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Blau, T. Neff, and T. Papayannopoulou
Cytokine Prestimulation as a Gene Therapy Strategy: Implications for Using the MDR1 Gene as a Dominant Selectable Marker
Blood,
January 1, 1997;
89(1):
146 - 154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Bensinger, R. Clift, C Anasetti, F. Appelbaum, T Demirer, S Rowley, B. Sandmaier, B Torok-Storb, R Storb, and C. Buckner
Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony stimulating factor
Stem Cells,
January 1, 1996;
14(1):
90 - 105.
[Abstract]
|
|
|
|
|
