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Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the
respiratory burst in human monocytes
BJ Rollins, A Walz and M Baggiolini
Division of Medicine, Dana-Farber Cancer Institute, Harvard Medical School,
Boston, Massachusetts.
The JE gene was first described as a platelet-derived growth factor
(PDGF)-inducible gene in mouse 3T3 cells. The human homologue of JE encodes
a protein whose predicted amino acid sequence is identical to that of the
monocyte chemoattractant MCP-1 (also called MCAF and SMC- CF), which
belongs to a recently identified family of small secretory proteins with
cytokine properties. We purified recombinant human MCP- 1/JE (hMCP-1/JE)
produced in COS cells and demonstrated that it is chemotactic for human
monocytes with a specific activity similar to natural MCP-1. In addition,
pure recombinant hMCP-1/JE stimulates monocytes, inducing an increase in
cytosolic free calcium and the respiratory burst, but is completely
inactive on human neutrophils. These results help to define functionally a
well-known growth factor- inducible gene and a member of a new family of
cytokines.
Volume 78,
Issue 4,
pp. 1112-1116,
08/15/1991
Copyright © 1991 by The American Society of Hematology
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