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The t(1;22) (p13;q13) is nonrandom and restricted to infants with acute
megakaryoblastic leukemia: a Pediatric Oncology Group Study
A Carroll, C Civin, N Schneider, G Dahl, A Pappo, P Bowman, A Emami, S Gross, C Alvarado and C Phillips
Laboratory of Medical Genetics, University of Alabama, Birmingham.
We report the nonrandom occurrence and frequency of the t(1;22)(p13;q13) in
acute myeloid leukemia (AML) and its close association with the
French-American-British M7 subtype of AML in infants (less than 1 year).
This chromosomal abnormality occurred in 6 of 252 (2.4%) children and
adolescents with AML (6 of 28 infants, 22%; 6 of 18 M7 AML cases overall,
33%; and 6 of 6 M7 cases in infants). Infants with AML of M7 subtype and
the t(1;22) often presented with prominent abdominal masses. Two of these
infants were not treated and died early. Three of four treated infants
entered complete remission with therapy for AML; the remaining infant died
of hemorrhage on day 8. Of the three infants who entered remission, only
one remains alive and disease free at 5+ months. The other two infants
relapsed in the bone marrow at 5 and 2 months from the start of therapy,
respectively. We conclude that M7 AML with the t(1;22) usually presents in
infants with extensive infiltration of abdominal organs by leukemic cells
and may confer a poor prognosis despite intensive AML-directed treatment.
Identification of this nonrandom translocation exclusively in infants with
acute megakaryoblastic leukemia (AMkL) implies that it may serve as an
additional diagnostic marker for this disease and links it to the
pathogenesis of AMkL in infants.
Volume 78,
Issue 3,
pp. 748-752,
08/01/1991
Copyright © 1991 by The American Society of Hematology
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