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Autoantibody activity of immunoglobulins isolated from B-cell follicular
lymphomas
G Dighiero, S Hart, A Lim, L Borche, R Levy and RA Miller
Institut Pasteur, Paris, France.
Previous work with monoclonal Igs (MIgs) has demonstrated that a high
proportion of paraproteins bind to self-antigens such as the Fc fragment of
IgG, Ii blood group antigens, cytoskeleton proteins, DNA, and
myelin-associated glycoprotein (MAG). Recent work in CLL indicates that
CD5+ B lymphocytes are frequently committed to production of
autoantibodies. We have examined the antibody specificity of MIgs derived
from the tumor cells of 31 different patients with CD5- B-cell lymphomas.
Our results indicate that the tumor cells from 8 of these 31 patients
(25.8%) express Igs with autoantibody activity. In two cases antibody
activity was multispecific. In four cases, antibody activity was
exclusively directed against the Fc fragment of IgG, whereas the two other
cases bound to both Fc fragment of IgG and nuclear antigens. Most
non-Hodgkin's lymphomas (NHL) are derived from CD5- B cells. These results
indicate that like CLL, NHL also express Igs that frequently have
autoantibody activity.
Volume 78,
Issue 3,
pp. 581-585,
08/01/1991
Copyright © 1991 by The American Society of Hematology
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