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Constitutive production of interleukin-6 and tumor necrosis factor- alpha
from spontaneously proliferating T cells in patients with human T- cell
lymphotropic virus type-I/II
RB Lal and DL Rudolph
Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, GA 30333.
The human T-cell lymphotropic viruses (HTLV) type I and type II are capable
of inducing a variety of cellular genes, including many of the cytokines
that regulate cell proliferation. To determine if the spontaneous
proliferation of peripheral blood mononuclear cells from patients infected
with HTLV-I and HTLV-II was related to coordinate expression of cytokines,
we analyzed the levels of interleukin-1 beta (IL-1 beta), IL-2, IL-3, IL-4,
IL-6, tumor necrosis factor-alpha (TNF- alpha) and interferon-tau (IFN-tau)
in culture supernatants derived from spontaneously proliferating cells.
Significantly elevated levels of IL-6 and TNF-alpha were present in culture
supernatants from HTLV- I/II-infected individuals when compared with normal
controls (P less than .01). Kinetic experiments showed that both IL-6 and
TNF-alpha were elevated by day 5. None of the other cytokines (IL-1 beta,
IL-2, IL-3, IL-4, and IFN-tau) were detectable in any of the culture. These
data suggest that release of IL-6 and TNF-alpha may regulate lymphocyte
proliferation in HTLV-I/II-infected individuals.
Volume 78,
Issue 3,
pp. 571-574,
08/01/1991
Copyright © 1991 by The American Society of Hematology
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