|
|
 Previous Article | Table of Contents | Next Article 
Effect of fibrinogen concentration on the velocity of platelet aggregation
R Landolfi, R De Cristofaro, E De Candia, B Rocca and B Bizzi
Centro Ricerche Fisiopatologia dell'Emostasi, Istituto di Semeiotica Medica
Universita Cattolica del Sacro Cuore, Roma, Italy.
The relationship between fibrinogen binding to its receptor and platelet
aggregation has been investigated by comparing 125I-fibrinogen binding and
aggregation velocities of gel-filtered platelets in the presence of
adenosine diphosphate (ADP). Aggregometric responses at various fibrinogen
concentrations are found to be bell-shaped and show a maximum at fibrinogen
concentrations (Fmax) similar to the 125I- fibrinogen hemisaturating doses.
At higher and lower fibrinogen concentrations, platelet aggregation
velocities decrease in a parallel manner. Lowering ADP concentration
increases Fmax, in agreement with the modulatory effect of ADP on
fibrinogen binding to platelets. Variations of fibrinogen in the range of
physiopathologic plasma concentrations affect platelet aggregation induced
by any ADP dose. These results clarify the relationship between the
fibrinogen binding process and aggregation and demonstrate that plasma
fibrinogen concentration has a major influence on the velocity of platelet
aggregation.
Volume 78,
Issue 2,
pp. 377-381,
07/15/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. Feng, K. Lindpaintner, M. G. Larson, C. J. O'Donnell, I. Lipinska, P. A. Sutherland, M. Mittleman, J. E. Muller, R. B. D'Agostino, D. Levy, et al.
Platelet Glycoprotein IIIa PlA Polymorphism, Fibrinogen, and Platelet Aggregability: The Framingham Heart Study
Circulation,
July 10, 2001;
104(2):
140 - 144.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-R. Nofer, M. Walter, B. Kehrel, S. Wierwille, M. Tepel, U. Seedorf, and G. Assmann
HDL3-Mediated Inhibition of Thrombin-Induced Platelet Aggregation and Fibrinogen Binding Occurs via Decreased Production of Phosphoinositide-Derived Second Messengers 1,2-Diacylglycerol and Inositol 1,4,5-tris-Phosphate
Arterioscler. Thromb. Vasc. Biol.,
June 1, 1998;
18(6):
861 - 869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Endenburg, L. Lindeboom-Blokzijl, J. J. Zwaginga, J. J. Sixma, and P. G. de Groot
Plasma Fibrinogen Inhibits Platelet Adhesion in Flowing Blood to Immobilized Fibrinogen
Arterioscler. Thromb. Vasc. Biol.,
May 1, 1996;
16(5):
633 - 638.
[Abstract]
[Full Text]
|
|
|
|
|
