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Selective expression of two homeobox genes in CD34-positive cells from
human bone marrow
Y Deguchi and JH Kehrl
Laboratory of Immunoregulation, National Institute of Allergy and
Infectious Diseases, National Institutes of Health, Bethesda, MD.
Proteins coded by homeobox-containing genes are sequence-specific DNA-
binding proteins that have been implicated in the control of gene
expression both in developing as well as in adult tissues. Two recently
characterized human homeobox genes, HB24 and HB9, were found to be highly
expressed in bone marrow cells enriched for CD34-positive cells, present at
low levels in unfractionated bone marrow cells, and essentially
undetectable in bone marrow cells depleted of CD34 cells. Treatment of
CD34-enriched cells with recombinant interleukin-3 (IL-3) and granulocyte
macrophage-colony-stimulating factor for 24 hours increased expression of
HB24 threefold and HB9 fourfold. Based on studies with actinomycin D, the
HB24 and HB9 transcripts in human CD34- positive cells have short
half-lives, estimated to be 30 to 45 minutes. Downregulation of HB24 and
HB9 expression was found following the treatment of in vitro cultures of
CD34-positive cells with IL-3. Thus, the differentiation of CD34-positive
cells along a specific cell lineage likely requires downregulation of both
HB24 and HB9.
Volume 78,
Issue 2,
pp. 323-328,
07/15/1991
Copyright © 1991 by The American Society of Hematology
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