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Increased incidence of solid malignant tumors after bone marrow
transplantation for severe aplastic anemia [see comments]
G Socie, M Henry-Amar, JM Cosset, A Devergie, T Girinsky and E Gluckman
Bone Marrow Transplant Unit, Hopital Saint-Louis, Paris, France.
From May 1980 to December 1989, 107 consecutive patients with non-
constitutional severe aplastic anemia underwent bone marrow transplantation
at our institution using cyclophosphamide and thoraco- abdominal
irradiation as conditioning regimen. During the same period, 40 patients
with Fanconi anemia were also grafted after a similar conditioning, giving
a total series of 147 patients. With a mean follow- up of 64 months, four
male patients developed a solid malignant tumor, a number that leads to an
8-year cumulative incidence rate of 22% (eg, relative risk to general
population = 41, P less than .001). These results should be considered as a
warning to clinicians who follow these successfully grafted long-term
patients.
Volume 78,
Issue 2,
pp. 277-279,
07/15/1991
Copyright © 1991 by The American Society of Hematology
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