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Iron absorption in hypotransferrinemic mice [see comments]
SS Buys, CB Martin, M Eldridge, JP Kushner and J Kaplan
Department of Medicine, University of Utah School of Medicine, Salt Lake
City, 84132.
We used a unique animal model, the hypotransferrinemic (Htx) mouse, to
examine the role of transferrin (Tf) in gastrointestinal iron uptake.
Despite the absence of Tf, Htx animals hyperabsorb iron. Transfusion of red
blood cells sufficient to normalize the hematocrit and reticulocyte count
resulted in a return of iron absorption to normal values. These studies
indicate that Tf does not play an obligate role in iron absorption, either
as a carrier or as a humoral signal regulating absorption. Transfer of
plasma or whole blood from Htx mice or from other animal models of iron
hyperabsorption to normal mice did not cause an increase in iron absorption
in recipient animals. Using the plasma or blood transfer approach, we have
been unable to detect a humoral regulator of gastrointestinal iron
absorption.
Volume 78,
Issue 12,
pp. 3288-3290,
12/15/1991
Copyright © 1991 by The American Society of Hematology
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