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Inhibitory effect of granulocyte-macrophage colony-stimulating factor
therapy on the generation of natural killer cells
A Shibuya, K Taguchi, H Kojima and T Abe
Division of Hematology, University of Tsukuba, Ibaraki, Japan.
We investigated the effects of recombinant human granulocyte-macrophage
colony-stimulating factor (rhGM-CSF) and recombinant human granulocyte
colony-stimulating factor (rhG-CSF) therapy on the natural killer (NK) cell
lineage in patients with aplastic anemia and myelodysplastic syndrome.
Selected bone marrow (BM) cells were prepared by the elimination of nylon
wool-adherent cells and mature T and NK cells from BM cells. The frequency
of BM NK progenitors relative to BM cells selected was significantly
decreased 4 weeks after the start of rhGM- CSF therapy (P less than .01),
while the peripheral blood NK cell count and NK activity were also
significantly decreased (P less than .05). A return to the pretreatment
levels was seen 4 weeks after the cessation of treatment in all cases. No
suppressive effect was noted in the patients who received rhG-CSF therapy.
These results suggest that rhGM- CSF therapy suppresses the generation of
NK cells from human BM NK progenitors.
Volume 78,
Issue 12,
pp. 3241-3247,
12/15/1991
Copyright © 1991 by The American Society of Hematology
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