|
|
 Previous Article | Table of Contents | Next Article 
Long-term results of therapy with interferon-alpha for type II essential
mixed cryoglobulinemia
M Casato, B Lagana, G Antonelli, F Dianzani and L Bonomo
Third Department of Internal Medicine, University of Rome La Sapienza,
School of Medicine, Italy.
Severe type II essential mixed cryoglobulinemia (EMC) bears a poor
prognosis. Treatment with corticosteroids and/or cytotoxic drugs
infrequently results in long-term remissions, and is associated with
significant toxicity. We conducted a prospective study with interferon
(IFN) in 21 patients with severe type II EMC unresponsive to
immunosuppressive regimens. They were treated with recombinant IFN- alpha
2a (18 patients) or with natural IFN-beta (three patients), alone, at a
dosage of 3 megaunits (MU)/d for 3 months, followed by 3 MU every other day
as maintenance. We observed 11 complete remissions, five partial
remissions, and five minor responses. Of 16 patients observed for more than
1 year, 11 remained in remission for 14 to 40 months; five of them remained
in complete remission for 18 to 40 months after withdrawal of treatment.
Four patients discontinued treatment because of side effects. In four
patients who relapsed while on maintenance therapy with recombinant
IFN-alpha 2a, remission could be reinduced by treatment with natural
IFN-alpha. The response rate of 77% achieved in this study prompts the use
of IFN-alpha as a first-choice drug for type II EMC.
Volume 78,
Issue 12,
pp. 3142-3147,
12/15/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. Sansonno, A. Carbone, V. De Re, and F. Dammacco
Hepatitis C virus infection, cryoglobulinaemia, and beyond
Rheumatology,
April 1, 2007;
46(4):
572 - 578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sansonno, V. De Re, G. Lauletta, F. A. Tucci, M. Boiocchi, and F. Dammacco
Monoclonal antibody treatment of mixed cryoglobulinemia resistant to interferon alpha with an anti-CD20
Blood,
May 15, 2003;
101(10):
3818 - 3826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Scagnolari, M. Casato, F. Bellomi, F. De Pisa, O. Turriziani, R. Coviello, M. R. Pirro, F. Dianzani, and G. Antonelli
Serum Interferon (IFN)-Neutralizing Antibodies and Bioactivities of IFNs in Patients with Severe Type II Essential Mixed Cryoglobulinemia
Clin. Vaccine Immunol.,
January 1, 2003;
10(1):
70 - 77.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Rieu, P. Cohen, M.-H. Andre, L. Mouthon, P. Godmer, B. Jarrousse, F. Lhote, F. Ferriere, P. Deny, P. Buchet, et al.
Characteristics and outcome of 49 patients with symptomatic cryoglobulinaemia
Rheumatology,
March 1, 2002;
41(3):
290 - 300.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P Cresta, L Musset, P Cacoub, L Frangeul, D Vitour, T Poynard, P Opolon, D-T Nguyen, F Golliot, J-C Piette, et al.
Response to interferon alpha treatment and disappearance of cryoglobulinaemia in patients infected by hepatitis C virus
Gut,
July 1, 1999;
45(1):
122 - 128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Casato, B. Lagana, L. P. Pucillo, and I. Quinti
Interferon for Hepatitis C Virus-Negative Type II Mixed Cryoglobulinemia
N. Engl. J. Med.,
May 7, 1998;
338(19):
1386 - 1387.
[Full Text]
|
|
|
|
|
|
|
M. Casato, V. Agnello, L. P. Pucillo, G. B. Knight, M. Leoni, S. Del Vecchio, C. Mazzilli, G. Antonelli, and L. Bonomo
Predictors of Long-Term Response to High-Dose Interferon Therapy in Type II Cryoglobulinemia Associated With Hepatitis C Virus Infection
Blood,
November 15, 1997;
90(10):
3865 - 3873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Misiani, P. Bellavita, D. Fenili, O. Vicari, D. Marchesi, P. L. Sironi, P. Zilio, A. Vernocchi, M. Massazza, G. Vendramin, et al.
Interferon Alfa-2a Therapy in Cryoglobulinemia Associated with Hepatitis C Virus
N. Engl. J. Med.,
March 17, 1994;
330(11):
751 - 756.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. Misiani, P. Bellavita, D. Fenili, P. Cacoub, F. Lunel, L. Musset, P. Opolon, J.-C. Piette, C. Werner, H. I. Joller-Jemelka, et al.
Hepatitis C Virus and Cryoglobulinemia
N. Engl. J. Med.,
April 15, 1993;
328(15):
1121 - 1124.
[Full Text]
|
|
|
|
|
