|
|
 Previous Article | Table of Contents | Next Article 
Thrombomodulin expression by human blood monocytes and by human synovial
tissue lining macrophages
SS McCachren, J Diggs, JB Weinberg and WA Dittman
Division of Geriatrics, Durham Veterans Administration Medical Center, NC
27705.
Thrombomodulin is an essential cofactor for the activation of the
anticoagulant protein C by thrombin. We have identified the expression of
thrombomodulin messenger RNA (mRNA) and protein in peripheral blood
monocytes. While untreated monocytes expressed thrombomodulin mRNA by
Northern blot analysis, lipopolysaccharide-treated cells had decreased mRNA
expression. Thrombomodulin antigen was shown in the cytoplasm and on the
surface of monocytes by immunohistochemical staining, and thrombomodulin
activity was shown on the surface of intact monocytes. One population of
synovial lining cells that normally expressed mononuclear phagocyte
antigens also expressed thrombomodulin in both noninflamed osteoarthritic
synovium and in inflamed rheumatoid arthritis synovium. However, these
cells did not express another endothelial protein, von Willebrand factor.
We conclude that both circulating and tissue mononuclear phagocytes are
capable of expressing thrombomodulin.
Volume 78,
Issue 12,
pp. 3128-3132,
12/15/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. V. de Wouwer, D. Collen, and E. M. Conway
Thrombomodulin-Protein C-EPCR System: Integrated to Regulate Coagulation and Inflammation
Arterioscler. Thromb. Vasc. Biol.,
August 1, 2004;
24(8):
1374 - 1383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Favre, M. Mancuso, K. Maas, J. W. McLean, P. Baluk, and D. M. McDonald
Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung
Am J Physiol Heart Circ Physiol,
November 1, 2003;
285(5):
H1917 - H1938.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Conway, M. Van de Wouwer, S. Pollefeyt, K. Jurk, H. Van Aken, A. De Vriese, J. I. Weitz, H. Weiler, P. W. Hellings, P. Schaeffer, et al.
The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor {kappa}B and Mitogen-activated Protein Kinase Pathways
J. Exp. Med.,
September 2, 2002;
196(5):
565 - 577.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ikeda, H. Ishii, T. Higuchi, K. Sato, Y. Hayashi, K. Ikeda, and Y. Hirabayashi
Localization of Thrombomodulin in the Anterior Segment of the Human Eye
Invest. Ophthalmol. Vis. Sci.,
October 1, 2000;
41(11):
3383 - 3390.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Oka, E. C. Gabazza, Y. Taguchi, M. Yamaguchi, S. Nakashima, K. Suzuki, Y. Adachi, and I. Imoto
Role of Activated Protein C in Helicobacter pylori-Associated Gastritis
Infect. Immun.,
May 1, 2000;
68(5):
2863 - 2869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Kunz, H. A. Ireland, P. J. Stubbs, M. Kahan, G. C. Coulton, and D. A. Lane
Identification and characterization of a thrombomodulin gene mutation coding for an elongated protein with reduced expression in a kindred with myocardial infarction
Blood,
January 15, 2000;
95(2):
569 - 576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Tohda, K. Oida, Y. Okada, S. Kosaka, E. Okada, S. Takahashi, H. Ishii, and I. Miyamori
Expression of Thrombomodulin in Atherosclerotic Lesions and Mitogenic Activity of Recombinant Thrombomodulin in Vascular Smooth Muscle Cells
Arterioscler. Thromb. Vasc. Biol.,
December 1, 1998;
18(12):
1861 - 1869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Koyama, M. Shibakura, M. Ohsawa, R. Kamiyama, and S. Hirosawa
Anticoagulant Effects of 1alpha ,25-Dihydroxyvitamin D3 on Human Myelogenous Leukemia Cells and Monocytes
Blood,
July 1, 1998;
92(1):
160 - 167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M-C. Boffa and M. Karmochkine
Review : Thrombomodulin: an overview and potential implications in vascular disorders
Lupus,
January 1, 1998;
7(2_suppl):
S120 - S125.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. M. Conway, S. Pollefeyt, D. Collen, and M. Steiner-Mosonyi
The Amino Terminal Lectin-Like Domain of Thrombomodulin Is Required for Constitutive Endocytosis
Blood,
January 15, 1997;
89(2):
652 - 661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Weiler-Guettler, W. C. Aird, M. Husain, H. Rayburn, and R. D. Rosenberg
Targeting of Transgene Expression to the Vascular Endothelium of Mice by Homologous Recombination at the Thrombomodulin Locus
Circ. Res.,
February 1, 1996;
78(2):
180 - 187.
[Abstract]
[Full Text]
|
|
|
|
|
