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A novel human homeobox gene lies at the chromosome 10 breakpoint in
lymphoid neoplasias with chromosomal translocation t(10;14)
ID Dube, S Kamel-Reid, CC Yuan, M Lu, X Wu, G Corpus, SC Raimondi, WM Crist, AJ Carroll and J Minowada
University of Toronto Hospitals' Cancer Cytogenetics Program, Ontario,
Canada.
The translocation t(10;14)(q24;q11) is an acquired change seen in 4% to 7%
of T-cell acute lymphoblastic leukemias (T-ALL). We previously demonstrated
that the translocation juxtaposes the T-cell receptor (TCR) delta-chain
gene in chromosome 14q11 with a novel region in chromosome 10q24 and is
likely catalyzed by recombinases normally involved in the generation of
immunoglobulin and TCR diversity. We now present the sequence of a gene on
chromosome 10 that lies immediately telomeric of the breakpoints in nine
new ALL patients with acquired rearrangements in 10q24. The gene is a novel
human homeobox gene and is expressed in leukemic cells from ALL patients
with rearrangements in a defined chromosome 10 breakpoint cluster region,
but not in other adult tissues or cell lines. This new gene has been
designated HOX11. Our results strongly support a role for homeobox genes in
oncogenesis and may represent the first example of a human cancer in which
deregulated expression of an unaltered homeobox gene is involved in
tumorigenesis.
Volume 78,
Issue 11,
pp. 2996-3003,
12/01/1991
Copyright © 1991 by The American Society of Hematology
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