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Bone marrow from children in relapse with pre-B acute lymphoblastic
leukemia proliferates and disseminates rapidly in scid mice
S Kamel-Reid, M Letarte, M Doedens, A Greaves, B Murdoch, T Grunberger, T Lapidot, P Thorner, MH Freedman and RA Phillips
Department of Genetics and Pathology, Hospital for Sick Children, Toronto,
Ontario, Canada.
Bone marrow samples from patients with pre-B acute lymphoblastic leukemia
(pre-B ALL), either at diagnosis or at relapse, were transplanted into scid
mice to determine whether these freshly obtained leukemic cells could
proliferate in vivo and whether there were any differences in their in vivo
growth characteristics. Cells from three patients who relapsed within 13
months of diagnosis proliferated rapidly in the murine bone marrow, spleen,
and thymus, invaded peripheral organs, and resulted in morbidity and
mortality of the animals within 4 to 16 weeks. Cells from two patients who
relapsed 3.5 years after diagnosis grew much slower than the early relapse
samples, taking up to 30 weeks to infiltrate the bone marrow of recipient
mice. In contrast, leukemic cells were absent or were detected at low
numbers in scid mice transplanted with cells obtained at diagnosis from
three patients who have not yet relapsed. These results show an increased
ability of leukemic cells from patients with aggressive lymphoblastic
leukemia of poor prognosis to proliferate in scid mice.
Volume 78,
Issue 11,
pp. 2973-2981,
12/01/1991
Copyright © 1991 by The American Society of Hematology
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