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E Berman, A Strife, D Wisniewski, S Desai, S Gulati, S Jhanwar and BD Clarkson
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York,
NY 10021.
The molecular events that allow for clonal expansion of the malignant
population in chronic myelogenous leukemia (CML) are poorly understood.
Recent experiments in transgenic mice suggest a close temporal relationship
between expression of the aberrant protein and manifestation of a
hematologic neoplasm that resembles CML; tracing the same phenomenon in
humans has not been possible. We studied a patient who underwent autologous
bone marrow harvest after completion of chemotherapy and radiation therapy
for advanced stage Hodgkin's disease. At the time of harvest his peripheral
blood counts and bone marrow were morphologically normal. Sixteen months
later he developed the clinical manifestations of CML. Detailed molecular
evaluation of the harvested marrow showed that a small number of cells
contained the Philadelphia chromosome. The time interval required for
expansion of the malignant clone, as suggested by this particular patient,
was at least 16 months although it is recognized that this figure may be
variable.
This article has been cited by other articles:
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| Copyright © 1991 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
