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Eosinophils from patients with blood eosinophilia express transforming
growth factor beta 1
DT Wong, A Elovic, K Matossian, N Nagura, J McBride, MY Chou, JR Gordon, TH Rand, SJ Galli and PF Weller
Department of Oral Medicine and Oral Pathology, Harvard School of Dental
Medicine, Boston, MA 02115.
The infiltration of eosinophils into tissues during pathologic responses is
often associated with extracellular matrix alterations such as fibrosis.
Transforming growth factor-beta 1 (TGF-beta 1) is a well-characterized
multifunctional cytokine known to exert potent effects on the extracellular
matrix. In this report, we showed the production of TGF-beta 1 by human
eosinophils from patients with blood eosinophilia. Northern blot analysis
using RNA isolated from eosinophils purified from a patient with the
idiopathic hypereosinophilic syndrome (HES) detected the 2.5-kb TGF-beta 1
transcript. In situ hybridization and immunohistochemistry of leukocytes
from two patients with HES and two patients with blood eosinophilia
localized TGF-beta 1 messenger RNA (mRNA) and protein to eosinophils. No
other cell type contained TGF-beta 1 mRNA by in situ hybridization, whereas
other leukocytes contained detectable TGF-beta 1 protein by
immunohistochemistry. Eosinophils from four normal donors contained little
or no detectable TGF-beta 1 protein by immunohistochemistry, whereas
eosinophils from two of these four normal donors labeled weakly for
TGF-beta 1 mRNA by in situ hybridization. These results show that
eosinophils in the peripheral blood of patients with blood eosinophilia can
express TGF-beta 1, but that eosinophils in the blood of normal donors
contained little or no TGF-beta 1.
Volume 78,
Issue 10,
pp. 2702-2707,
11/15/1991
Copyright © 1991 by The American Society of Hematology
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