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Essential differences in oncogene involvement between primary nodal and
extranodal large cell lymphoma
S Raghoebier, MH Kramer, JH van Krieken, D de Jong, J Limpens, JC Kluin- Nelemans, GJ van Ommen and PM Kluin
Department of Hematology, University Medical Center, Leiden, The
Netherlands.
Large cell lymphomas (LCLs) are heterogeneous in morphology, clinical
presentation, and behavior. We studied 52 de novo LCLs of B-cell type for
rearrangements of the bcl-2 and c-myc oncogenes by Southern blot analysis
and related these data to the primary site of presentation, stage, and
cytomorphology. Thirteen tumors had comigrating rearrangements of JH and
bcl-2, indicative of a t(14;18). Far more primary nodal lymphomas than
extranodal lymphomas carried a t(14;18) (40% v less than 5%). Additionally,
almost all lymphomas with a t(14;18) versus 41% of the tumors without a
bcl-2 rearrangement presented with lymphadenopathy. c-myc rearrangements
were seen in 35% of the extranodal lymphomas and 5% of the nodal lymphomas.
No differences were observed in bone marrow involvement and staging
according to Ann Arbor. bcl-2 rearrangements were found in 50% of the LCLs
with cleaved nuclei, whereas c-myc rearrangements were relatively frequent
(25%) in the noncleaved subtype. Our data support the hypothesis that
primary nodal and extranodal lymphomas have a different genetic origin.
Volume 78,
Issue 10,
pp. 2680-2685,
11/15/1991
Copyright © 1991 by The American Society of Hematology
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