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Constitutive expression and role in growth regulation of interleukin-1 and
multiple cytokine receptors in a biphenotypic leukemic cell line
A Cohen, T Grunberger, W Vanek, ID Dube, PJ Doherty, M Letarte, C Roifman and MH Freedman
Division of Immunology and Cancer Research, Hospital for Sick Children,
Toronto, Ontario, Canada.
A cell line (B1) was established from the bone marrow of a patient with a
relapse of acute leukemia characterized by a 4;11 chromosomal translocation
and biphenotypic features of early B and myeloid lineages. Analysis of the
growth requirements of this cell line showed density-dependent growth and
secretion of an autostimulatory growth factor, suggesting an autocrine
mechanism. Several lines of evidence implicate the participation of
interleukin-1 (IL-1) in the autocrine growth regulation of B1 cells. These
cells constitutively express the messenger RNA (mRNA) for IL-1 and IL-1
receptor and secrete IL-1; recombinant IL-1 stimulated the growth of
colonies when cells were seeded at low density, and anti-IL-1 antibodies
inhibited the growth of colonies with cells seeded at higher density. B1
cells do not express detectable levels of mRNA for any of the other
cytokines tested, and other cytokines failed to support the growth of B1
cells at low density. In addition, B1 cells express multiple cytokine
receptor genes, including the receptors for IL-6, IL-7, tumor necrosis
factor and gamma-interferon. Addition of the respective cytokines to the B1
cells resulted in inhibition of the growth of leukemic cells in vitro. The
multiplicity of growth-inhibitory cytokine receptors on this leukemic cell
line might be due to its biphenotypic lineage and may suggest new
therapeutic possibilities in controlling leukemic cell proliferation.
Volume 78,
Issue 1,
pp. 94-102,
07/01/1991
Copyright © 1991 by The American Society of Hematology
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