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Identification of stromal cell precursors in human bone marrow by a novel
monoclonal antibody, STRO-1
PJ Simmons and B Torok-Storb
Department of Medical Oncology, Fred Hutchinson Cancer Research Center,
Seattle, WA 98104.
Murine IgM monoclonal antibody STRO-1 identifies a cell surface antigen
expressed by stromal elements in human bone marrow (BM). STRO-1 binds to
approximately 10% of BM mononuclear cells, greater than 95% of which are
nucleated erythroid precursors, but does not react with committed
progenitor cells (colony-forming unit granulocyte-macrophage [CFU-GM],
erythroid bursts [BFU-E], and mixed colonies [CFU-Mix]). Fibroblast
colony-forming cells (CFU-F) are present exclusively in the STRO-1+
population. Dual-color cell sorting using STRO-1 in combination with
antibody to glycophorin A yields a population approximately 100-fold
enriched in CFU-F in the STRO-1+/glycophorin A+ population. When plated
under long-term BM culture (LTBMC) conditions, STRO-1+ cells generate
adherent cell layers containing multiple stromal cell types, including
adipocytes, smooth muscle cells, and fibroblastic elements. STRO-1+ cells
isolated from LTBMC at later times retain the capacity to generate adherent
layers with a cellular composition identical to that of the parent
cultures. The STRO-1-selected adherent layers are able to support the
generation of clonogenic cells and mature hematopoietic cells from a
population of CD34+ cells highly enriched in so-called long-term
culture-initiating cells. We conclude that antibody STRO-1 binds to BM
stromal elements with the capacity to transfer the hematopoietic
microenvironment in vitro.
Volume 78,
Issue 1,
pp. 55-62,
07/01/1991
Copyright © 1991 by The American Society of Hematology
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