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Oncogene rearrangements in chronic B-cell leukemia
S Raghoebier, JH van Krieken, JC Kluin-Nelemans, A Gillis, GJ van Ommen, AM Ginsberg, M Raffeld and PM Kluin
Department of Pathology, University of Leiden, The Netherlands.
Forty-four B-chronic lymphocytic leukemias (CLL) were studied by Southern
blot analysis using probes for the Ig genes and bcl-1, bcl-2 (major, minor
and 5' breakpoint region), bcl-3, c-myc, and retinoblastoma (Rb) loci.
Eight cases had three or more rearranged JH bands, indicating
oligoclonality, clonal evolution, or chromosomal translocation. One case
had a rearrangement of the bcl-1 locus and three of the bcl-2 locus. In the
first case, comigration of the rearranged bcl-1 and JH sequences indicated
a t(11;14)(q13;q32) translocation, which, in contrast to previously
described cases, seems to be completely reciprocal. One case with a bcl-2
rearrangement showed comigration of the bcl-2 major breakpoint region and a
rearranged JH band. This indicates a t(14;18) (q32;q21). The two other
cases showed rearrangements of the bcl-2 5' breakpoint region without
apparent comigration. No rearrangements were detected of c-myc and bcl-3,
located at chromosome 19, nor was a deletion of Rb found. All but three
cases had CD5 expression. The exceptions included the t(11;14) and the
t(14;18) cases. Our results confirm recent data on rearrangements at the 5'
site of bcl-2 in CLL. Additionally, they corroborate the presumption that
CD5-negative chronic B-cell leukemias should be considered apart from
classical CLL.
Volume 77,
Issue 7,
pp. 1560-1564,
04/01/1991
Copyright © 1991 by The American Society of Hematology
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