|
|
 Previous Article | Table of Contents | Next Article 
Cytogenetic analysis of 434 consecutively ascertained specimens of non-
Hodgkin's lymphoma: clinical correlations
K Offit, G Wong, DA Filippa, Y Tao and RS Chaganti
Laboratory of Cancer Genetics, Sloan-Kettering Institute, New York, NY.
Cytogenetic and histopathologic data were correlated with clinical
parameters from 423 patients with non-Hodgkin's lymphoma (NHL). Clinical
correlations were performed on subgroups of 149 patients with low-grade
lymphoma (LG) and 205 patients with diffuse lymphoma with a large cell
component (DLLC). Correlations were made between clinical outcome and
individual recurring cytogenetic aberrations, each of which was noted in
greater than 5% of cases belonging to LG NHL and DLLC, and derived measures
of karyotypic complexity, comprising modal chromosome number, number of
marker chromosomes, and number of translocation breakpoints. No
correlations with survival were noted in LG NHL, although median follow-up
was only 2 years. Seven patients with t(8;14) LG NHL had an indolent
course. Among 104 patients with DLLC and abnormal karyotypes at diagnosis,
breaks at 1q21-23 or more than 4 marker chromosomes was associated with a
shortened median survival. Using these variables we constructed a
proportional hazards model with a good fit to observed data. Breaks at
6q21-25 predicted a decreased probability of achieving remission. Patients
with DLLC and breaks at 1q21-23 or 1p32-36 had a shorter duration of
complete remission. Of 41 DLLC studied at relapse, the only long-term
survivors had t(14;18).
Volume 77,
Issue 7,
pp. 1508-1515,
04/01/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Le Gouill, P. Talmant, C. Touzeau, A. Moreau, R. Garand, N. Juge-Morineau, F. Gaillard, T. Gastinne, N. Milpied, P. Moreau, et al.
The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement
Haematologica,
October 1, 2007;
92(10):
1335 - 1342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Haga, G. R. A. Ehrhardt, R. J. Boohaker, R. S. Davis, and M. D. Cooper
Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment
PNAS,
June 5, 2007;
104(23):
9770 - 9775.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Abramson and M. A. Shipp
Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach
Blood,
August 15, 2005;
106(4):
1164 - 1174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Katzenberger, G. Ott, T. Klein, J. Kalla, H. K. Muller-Hermelink, and M. M. Ott
Cytogenetic Alterations Affecting BCL6 Are Predominantly Found in Follicular Lymphomas Grade 3B with a Diffuse Large B-Cell Component
Am. J. Pathol.,
August 1, 2004;
165(2):
481 - 490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Viardot, P. Moller, J. Hogel, K. Werner, G. Mechtersheimer, A. D. Ho, G. Ott, T. F.E. Barth, R. Siebert, S. Gesk, et al.
Clinicopathologic Correlations of Genomic Gains and Losses in Follicular Lymphoma
J. Clin. Oncol.,
December 1, 2002;
20(23):
4523 - 4530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Gozzetti, E. M. Davis, R. Espinosa III, A. A. Fernald, J. Anastasi, and M. M. Le Beau
Identification of Novel Cryptic Translocations Involving IGH in B-Cell Non-Hodgkin's Lymphomas
Cancer Res.,
October 1, 2002;
62(19):
5523 - 5527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Nanjangud, P. H. Rao, A. Hegde, J. Teruya-Feldstein, G. Donnelly, J. Qin, S. C. Jhanwar, A. D. Zelenetz, and R. S. K. Chaganti
Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma
Blood,
April 1, 2002;
99(7):
2554 - 2561.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Husson, E. G. Carideo, D. Neuberg, J. Schultze, O. Munoz, P. W. Marks, J. W. Donovan, A. C. Chillemi, P. O'Connell, and A. S. Freedman
Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays
Blood,
January 1, 2002;
99(1):
282 - 289.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Zhou, A. Zettl, P. Strobel, K. Wagner, H. K. Muller-Hermelink, S.-j. Zhang, A. Marx, and P. Starostik
Thymic Epithelial Tumors Can Develop along Two Different Pathogenetic Pathways
Am. J. Pathol.,
November 1, 2001;
159(5):
1853 - 1860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Straus, E. S. Jaffe, J. M. Puck, J. K. Dale, K. B. Elkon, A. Rosen-Wolff, A. M. J. Peters, M. C. Sneller, C. W. Hallahan, J. Wang, et al.
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis
Blood,
July 1, 2001;
98(1):
194 - 200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Itoyama, R. S. K. Chaganti, Y. Yamada, K. Tsukasaki, S. Atogami, H. Nakamura, M. Tomonaga, K. Ohshima, M. Kikuchi, and N. Sadamori
Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki
Blood,
June 1, 2001;
97(11):
3612 - 3620.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. L. P. Siu, V. Chan, J. K. C. Chan, K.-F. Wong, R. Liang, and Y.-L. Kwong
Consistent Patterns of Allelic Loss in Natural Killer Cell Lymphoma
Am. J. Pathol.,
December 1, 2000;
157(6):
1803 - 1809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. G. Willis and M. J. S. Dyer
The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies
Blood,
August 1, 2000;
96(3):
808 - 822.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cuneo, R. Bigoni, G. M. Rigolin, M. G. Roberti, R. Milani, A. Bardi, C. Minotto, P. Agostini, C. De Angeli, M. G. Narducci, et al.
Acquired Chromosome 11q Deletion Involving the Ataxia Teleangiectasia Locus in B-Cell Non-Hodgkin's Lymphoma: Correlation With Clinicobiologic Features
J. Clin. Oncol.,
July 1, 2000;
18(13):
2607 - 2614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Gilles, A. Goy, Y. Remache, P. Shue, and A. D. Zelenetz
MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma
Blood,
May 1, 2000;
95(9):
2930 - 2936.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Akasaka, H. Akasaka, C. Ueda, N. Yonetani, Y. Maesako, A. Shimizu, H. Yamabe, S. Fukuhara, T. Uchiyama, and H. Ohno
Molecular and Clinical Features of Non-Burkitt’s, Diffuse Large-Cell Lymphoma of B-Cell Type Associated With the c-MYC/Immunoglobulin Heavy-Chain Fusion Gene
J. Clin. Oncol.,
February 1, 2000;
18(3):
510 - 510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Callanan, P. Le Baccon, P. Mossuz, S. Duley, C. Bastard, R. Hamoudi, M. J. Dyer, G. Klobeck, R. Rimokh, J. J. Sotto, et al.
The IgG Fc receptor, Fcgamma RIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma
PNAS,
January 4, 2000;
97(1):
309 - 314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Macintyre, D. Willerford, and S. W. Morris
Non-Hodgkin's Lymphoma: Molecular Features of B Cell Lymphoma
Hematology,
January 1, 2000;
2000(1):
180 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kudoh, M. Takano, T. Koshikawa, M. Hirai, S. Yoshida, Y. Mano, K. Yamamoto, K. Ishii, T. Kita, Y. Kikuchi, et al.
Gains of 1q21-q22 and 13q12-q14 Are Potential Indicators for Resistance to Cisplatin-based Chemotherapy in Ovarian Cancer Patients
Clin. Cancer Res.,
September 1, 1999;
5(9):
2526 - 2531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Dave, M. M. Hess, D. L. Pickering, D. H. Zaleski, A. L. Pfeifer, D. D. Weisenburger, J. O. Armitage, and W. G. Sanger
Rearrangements of Chromosome Band 1p36 in Non-Hodgkin's Lymphoma
Clin. Cancer Res.,
June 1, 1999;
5(6):
1401 - 1409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cuneo, R. Bigoni, G. M. Rigolin, M. G. Roberti, A. Bardi, N. Piva, R. Milani, F. Bullrich, M. L. Veronese, C. Croce, et al.
Cytogenetic Profile of Lymphoma of Follicle Mantle Lineage: Correlation With Clinicobiologic Features
Blood,
February 15, 1999;
93(4):
1372 - 1380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hatta, Y. Yamada, M. Tomonaga, I. Miyoshi, J. W. Said, and H. P. Koeffler
Detailed Deletion Mapping of the Long Arm of Chromosome 6 in Adult T-Cell Leukemia
Blood,
January 15, 1999;
93(2):
613 - 616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.H.H. Kramer, J. Hermans, E. Wijburg, K. Philippo, E. Geelen, J.H.J.M. van Krieken, D. de Jong, E. Maartense, E. Schuuring, and P.M. Kluin
Clinical Relevance of BCL2, BCL6, and MYC Rearrangements in Diffuse Large B-Cell Lymphoma
Blood,
November 1, 1998;
92(9):
3152 - 3162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Sakai, C. Thieblemont, A. Wellmann, E. S. Jaffe, and M. Raffeld
PTEN Gene Alterations in Lymphoid Neoplasms
Blood,
November 1, 1998;
92(9):
3410 - 3415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Friess, Z Lu, H U Graber, A Zimmermann, G Adler, M Korc, R M Schmid, and M W Buchler
bax, but not bcl-2, influences the prognosis of human pancreatic cancer
Gut,
September 1, 1998;
43(3):
414 - 421.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. H. Rao, J. Houldsworth, K. Dyomina, N. Z. Parsa, J. C. Cigudosa, D. C. Louie, L. Popplewell, K. Offit, S. C. Jhanwar, and R.S.K. Chaganti
Chromosomal and Gene Amplification in Diffuse Large B-Cell Lymphoma
Blood,
July 1, 1998;
92(1):
234 - 240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Nicolaides, S. Dimou, and N. Pavlidis
Prognostic Factors in Aggressive Non-Hodgkin's Lymphomas
Oncologist,
June 1, 1998;
3(3):
189 - 197.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. F.E. Barth, H. Dohner, C. A. Werner, S. Stilgenbauer, M. Schlotter, M. Pawlita, P. Lichter, P. Moller, and M. Bentz
Characteristic Pattern of Chromosomal Gains and Losses in Primary Large B-Cell Lymphomas of the Gastrointestinal Tract
Blood,
June 1, 1998;
91(11):
4321 - 4330.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.G. Willis, I.R. Zalcberg, L.J.A. Coignet, I. Wlodarska, M. Stul, D.M. Jadayel, C. Bastard, J.G. Treleaven, D. Catovsky, M.L.M. Silva, et al.
Molecular Cloning of Translocation t(1;14)(q21;q32) Defines a Novel Gene (BCL9) at Chromosome 1q21
Blood,
March 15, 1998;
91(6):
1873 - 1881.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Offit, F. L. Coco, D. C. Louie, N. Z. Parsa, D. Leung, C. Portlock, B. H. Ye, F. Lista, D. A. Filippa, A. Rosenbaum, et al.
Rearrangement of the bcl-6 Gene as a Prognostic Marker in Diffuse Large-Cell Lymphoma
N. Engl. J. Med.,
July 14, 1994;
331(2):
74 - 80.
[Abstract]
[Full Text]
|
|
|
|
|
