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2.5S nerve growth factor enhances survival, phagocytosis, and superoxide
production of murine neutrophils
Y Kannan, H Ushio, H Koyama, M Okada, M Oikawa, T Yoshihara, M Kaneko and H Matsuda
Department of Veterinary Surgery, College of Agriculture, University of
Osaka Prefecture, Japan.
The effect of 2.5S nerve growth factor (NGF) on survival, phagocytosis, and
superoxide production of murine neutrophils was examined and compared with
the effects of interleukin-3 (IL-3) and recombinant GM colony-stimulating
factor (rGM-CSF). NGF enhanced the viability of neutrophils isolated from
peripheral blood and peritoneal cavity in a dose-dependent way. IL-3 50
U/mL had no effect. rGM-CSF 50 U/mL had an effect similar to that of 50
ng/mL NGF. NGF also enhanced the phagocytosis of hydrophilic microspheres
by peritoneal neutrophils, and the activity of NGF was greater than that of
IL-3 or rGM-CSF. NGF enhanced the superoxide production induced by phorbol
12-myristate 13- acetate (PMA), which acts at postreceptor sites, and that
induced by opsonized zymosan, a receptor-mediated ligand. The stimulating
activity of NGF was largely comparable to that of rGM-CSF. The present data
show that NGF bound to neutrophils enhances their survival, phagocytosis,
and superoxide production. Thus, we postulate that NGF plays an important
role in the inflammatory processes.
Volume 77,
Issue 6,
pp. 1320-1325,
03/15/1991
Copyright © 1991 by The American Society of Hematology
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