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The effect of 5-fluorouracil on erythropoiesis
IN Rich
Department of Transfusion Medicine, University of Ulm, Germany.
The effects of a single dose (150 mg/kg) of 5-fluorouracil on mature
erythroid and erythropoietic and multipotential in vitro precursor
populations in the bone marrow and spleen and circulating biologically
(erythroid colony forming unit [CFU-E] assay) and immunologically active
(enzyme-linked immunosorbent assay) erythropoietin (Epo) are described. All
mature erythroid (reticulocytes, erythrocytes) and in vitro erythropoietic
precursors (CFU-E, erythroid burst-forming unit [BFU-E]) are severely
reduced, if not eradicated. Transient repopulation of the pure BFU-E and
CFU-E populations on days 6 and 7, respectively, produces a marked
reticulocytosis after day 9. Circulating Epo increases to above normal
values by day 2. However, whereas biologically active Epo remains constant
at this level until day 9, immunologically active Epo continually
increases; by day 12, however, both assays detect circulating Epo levels of
about 400 mU/mL. In vitro multipotential stem cells (BFU-E mix) are reduced
to 32% on day 1, 7.6% on day 2, and return to normal values between days 4
and 5. The survival and repopulation kinetics of the BFU-E mix imply a stem
cell population more mature than the high proliferative potential
colony-forming cells. However, the BFU-E mix may be responsible for
erythropoiesis repopulating ability.
Volume 77,
Issue 6,
pp. 1164-1170,
03/15/1991
Copyright © 1991 by The American Society of Hematology
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