|
|
 Previous Article | Table of Contents | Next Article 
Expression of intercellular adhesion molecule-1 (CD54) on hematopoietic
progenitors
S Arkin, B Naprstek, L Guarini, S Ferrone and JM Lipton
Division of Pediatric Hematology-Oncology, Mount Sinai School of Medicine,
New York, NY 10029.
The distribution of intercellular adhesion molecule-1 (ICAM-1), a ligand
for lymphocyte function antigen-1, on hematopoietic tissue was determined
using the anti-ICAM-1 monoclonal antibody CL203.4 with flow cytometry and
short-term semi-solid hematopoietic progenitor cultures. After timed
incubation in media with fetal bovine serum, 29% of erythroid burst-forming
units (BFU-E), 24% of erythroid colony-forming units (CFU-E), and 52% of
granulocyte-macrophage colony-forming units (CFU-GM) bone marrow
progenitors expressed ICAM-1. This finding, which is consistent with the
detection of ICAM-1 on acute non-lymphoblastic leukemic blasts, is at
variance with recent reports. ICAM-1 was also detected on bone marrow
blasts, proerythroblasts, promyelocytes, and cells of monocyte/macrophage
lineage, but was not detected on erythroblasts, normoblasts, neutrophilic
myelocytes, metamyelocytes, bands, or on most lymphocytes. These results
indicate that maturation of cells of the erythroid and myeloid lineage is
associated with loss of ICAM-1. The distribution of ICAM-1 on bone marrow
progenitors, early precursor cells, and accessory cells in conjunction with
the function of this molecule in cell-cell interactions suggests that
ICAM-1 may play a role in the cell-cell and cell-stromal interactions that
regulate hematopoiesis.
Volume 77,
Issue 5,
pp. 948-953,
03/01/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. Lee, A. Lo, S. A. Short, T. J. Mankelow, F. Spring, S. F. Parsons, K. Yazdanbakhsh, N. Mohandas, D. J. Anstee, and J. A. Chasis
Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation
Blood,
September 15, 2006;
108(6):
2064 - 2071.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Soni, S. Bala, B. Gwynn, K. E. Sahr, L. L. Peters, and M. Hanspal
Absence of Erythroblast Macrophage Protein (Emp) Leads to Failure of Erythroblast Nuclear Extrusion
J. Biol. Chem.,
July 21, 2006;
281(29):
20181 - 20189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Carter, J. L. MacDonald, and A. J. Roskams
Olfactory Horizontal Basal Cells Demonstrate a Conserved Multipotent Progenitor Phenotype
J. Neurosci.,
June 23, 2004;
24(25):
5670 - 5683.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Lee, F. A. Spring, S. F. Parsons, T. J. Mankelow, L. L. Peters, M. J. Koury, N. Mohandas, D. J. Anstee, and J. A. Chasis
Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions
Blood,
March 1, 2003;
101(5):
1790 - 1797.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. B.H. Geijtenbeek, Y. van Kooyk, S. J. van Vliet, M. H. Renes, R. A.P. Raymakers, and C. G. Figdor
High Frequency of Adhesion Defects in B-Lineage Acute Lymphoblastic Leukemia
Blood,
July 15, 1999;
94(2):
754 - 764.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
