Correlation between molecular and clinical events in the evolution of
chronic myelocytic leukemia to blast crisis
A Foti, HG Ahuja, SL Allen, P Koduru, MW Schuster, P Schulman, M Bar-Eli and MJ Cline
UCLA School of Medicine 90024-1678.
A patient with typical Philadelphia chromosome (Ph1)-positive chronic
myelocytic leukemia (CML) was studied during sequential phases of disease:
(1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic
phase; and (4) accelerated disease. A point mutation in the coding sequence
of the p53 gene first appeared concomitantly with the blast crisis and then
disappeared with the re-establishment of a second chronic phase. The
chromosomal concomitant of the molecular alteration was a deletion of 17p.
These observations suggest that abnormalities of the p53 anti-oncogene are
temporally related to the clinical progression of some cases of CML and are
probably responsible for the development of blast crisis in these cases.
Volume 77,
Issue 11,
pp. 2441-2444,
06/01/1991
Copyright © 1991 by The American Society of Hematology
