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Genotypic characterization of centrocytic lymphoma: frequent rearrangement
of the chromosome 11 bcl-1 locus
ME Williams, CD Westermann and SH Swerdlow
Department of Internal Medicine, University of Virginia Health Sciences
Center, Charlottesville 22908.
Centrocytic lymphomas are defined in the Kiel classification as B-cell
lymphomas composed exclusively of cells resembling cleaved follicular
center cells (FCC). These lymphomas have been shown to be histologically,
immunophenotypically, and clinically distinct from other cleaved FCC
lymphomas. DNA from 18 centrocytic lymphomas (14 patients) was analyzed
using Southern blotting and probes for immunoglobulin heavy (JH) and kappa
light chain (JK) joining gene, T- cell receptor beta chain constant gene
(CB), bcl-1, bcl-2, and c-myc gene rearrangements. All of the lymphomas had
JH and JK rearrangements, confirming their B-cell origin. None of the
specimens had detectable CB, bcl-2, or c-myc rearrangements. However, 4 of
14 patients (28.6%) had rearrangement of the chromosome 11 bcl-1 locus.
Therefore, centrocytic lymphomas are genotypically distinguishable from the
majority of other small cleaved FCC lymphomas by their lack of demonstrable
bcl-2 rearrangements. This supports the distinct nature of centrocytic
lymphomas and suggests the lack of importance for the putative oncogene
bcl-2 in these cases. Furthermore, the frequent rearrangement of bcl-1
suggests a possible role for this locus in the pathogenesis of at least
some centrocytic lymphomas.
Volume 76,
Issue 7,
pp. 1387-1391,
10/01/1990
Copyright © 1990 by The American Society of Hematology
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