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Next Article 
Inflammation and cancer: role of phagocyte-generated oxidants in
carcinogenesis
SA Weitzman and LI Gordon
Department of Medicine, Northwestern University Medical School, Chicago, IL
60611.
We have reviewed some of the data that link the reactive oxygen species
produced by inflammatory phagocytes to cancer development. While it is
clear that these substances induce phenotypic changes characteristic of
those produced by known carcinogens, the precise mechanisms by which these
effects are produced require much further study. In vitro, it would appear
that phagocyte-generated oxidants could be complete carcinogens, ie, could
cause both tumor initiation and promotion. In vivo, however, these
substances appear usually to function as tumor promoters or cocarcinogens
perhaps because of high levels of endogenous antioxidant defenses. This
suggests that there may be even more reason to be optimistic about the
potential for positive results in cancer chemoprevention trials in humans,
and provides further rationale for the continuing interest in the use of
antioxidants and anti- inflammatory drugs in current and future trials. For
example, the Chemoprevention Branch of the National Cancer Institute is
currently sponsoring seven extramural human efficacy intervention trials
testing whether the antioxidant beta carotene can prevent cancer.
Volume 76,
Issue 4,
pp. 655-663,
08/15/1990
Copyright © 1990 by The American Society of Hematology
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