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Consecutive enzyme cascades: complement activation at the cell surface
triggers increased tissue factor activity
SD Carson and DR Johnson
Department of Pathology and Microbiology, University of Nebraska Medical
Center, Omaha 68198-6495.
Complement activation at the cell surface initiates cell damage through a
series of reactions occurring at the cell membrane and, after assembly of
the terminal membrane attack complex, produces leakage of cytoplasmic
contents from the cell. It has been documented that chemical or physical
damage to cell membranes can cause a rapid increase in the expression of
tissue factor procoagulant activity. In this study, antibody-mediated
complement activation at the cell surface resulted in increased tissue
factor activity, which correlated with cytolysis, as measured by
51-chromium release. Therefore, complement fixation on the cell surface can
have a direct and immediate stimulatory effect on the coagulation cascade
at the point of its initiation, with formation of a fibrin clot requiring
only three consecutive proteolytic reactions after immunologically mediated
cell damage.
Volume 76,
Issue 2,
pp. 361-367,
07/15/1990
Copyright © 1990 by The American Society of Hematology
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