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Hairy cell leukemia preferentially expresses the IgG3-subclass

HC Kluin-Nelemans, MM Krouwels, JH Jansen, K Dijkstra, MJ van Tol, GJ den Ottolander, EJ Dreef and PM Kluin

Department of Hematomorphology and Immunotyping, University Hospital, Leiden, The Netherlands.

Surface IgG expression of 29 cases of hairy cell leukemia (HCL) was assessed using IgG-subclass-specific monoclonal and F(ab)'2 polyclonal antibodies. A marked preference for the IgG3 subclass was found, as 16 of 19 IgG-positive HCL's expressed IgG3. In 10 cases, IgG3 was concurrently expressed with other heavy chains. No preferential IgG3 expression was observed in 11 IgG-positive non-Hodgkin's lymphomas. The marked predominance of IgG3 in HCL suggests a deviation in heavy chain class switching that may be related to the characteristically very low expression of LFA-1 and ICAM-1 molecules on hairy cells, and hence a defect in T-cell hairy cell interaction.

Volume 75, Issue 4, pp. 972-975, 02/15/1990
Copyright © 1990 by The American Society of Hematology


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