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A comparison of hematopoiesis in normal and splenectomized mice treated
with granulocyte colony-stimulating factor
G Molineux, Z Pojda and TM Dexter
Paterson Institute for Cancer Research, Christie Hospital and Holt Radium
Institute, Withington, Manchester, UK.
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) induces
leukocytosis in vivo in both intact and splenectomized mice. Full dose
response data showed a plateau in this effect at doses over 500 micrograms
rhG-CSF/kg body weight/d in intact mice. The effect is magnified in
splenectomized mice, where leukocyte numbers reach 100 x 10(6) mL after 4
days' treatment at 250 micrograms/kg/d. Further hematopoietic precursor
populations are also affected in both marrow and the spleen; in general,
marrow parameters were depressed, while splenic populations were enlarged.
In splenectomized mice, both blood- borne stem cells were enhanced, and
foci of extramedullary hematopoiesis were enlarged in addition to the
effects seen in intact mice. In the marrow of splenectomized and intact
mice treated with a high dose of G-CSF, erythroid suppression in the marrow
was confirmed with radioactive iron. Our studies confirm and extend
previous work on the mode of action of G-CSF, and indicate that side
effects of high dose G-CSF therapy might include erythroid suppression in
the bone marrow.
Volume 75,
Issue 3,
pp. 563-569,
02/01/1990
Copyright © 1990 by The American Society of Hematology
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