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Transfusion-transmitted HTLV-I/II infection in patients undergoing open- heart surgery

JW Shih, HH Lee, M Falchek, M Canavaggio, BW Jett, JP Allain and HJ Alter

Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892.

Sera from 5,244 blood donations collected between 1979 and 1987 were screened for antibody to HTLV-I with an enzyme immunoassay (EIA) whose result was confirmed with a two-step procedure including Western blot (WB) and radio immunoprecipitation. Of 20 repeatedly reactive samples, two were confirmed positive for HTLV-I infection. These blood units were transfused to patients undergoing cardiac surgery. Both recipients of the confirmed anti-HTLV-I positive units were infected with HTLV-I as evidenced by antibody seroconversion. In contrast, six recipients of EIA positive, WB indeterminate blood and nine recipients WB negative blood were not infected with HTLV-I. These results confirm a low prevalence of HTLV-I infection in US blood donors, the capacity of infected units to transmit the virus to recipients, and the importance of an appropriate confirmatory assay.

Volume 75, Issue 3, pp. 546-549, 02/01/1990
Copyright © 1990 by The American Society of Hematology


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  Copyright © 1990 by American Society of Hematology         Online ISSN: 1528-0020