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Production of monoclonal antibodies that detect Hodgkin's high molecular weight transforming growth factor-beta

SR Newcom, LH Muth and ET Parker

Department of Medicine, Emory University School of Medicine, Atlanta, GA.

High molecular weight transforming growth factor-beta (TGF beta) is a physiologically active TGF secreted by nodular sclerosing Reed- Sternberg cells. Five monoclonal murine antibodies were prepared that distinguished Hodgkin's TGF beta from platelet-derived TGF beta using an enzyme-linked immunosorbent assay, neutralization of biologic activity, and Western blotting. These monoclonal antibodies directed at unique antigenic determinants (epitopes) of Hodgkin's TGF beta will allow further characterization of the role of Hodgkin's TGF beta in Hodgkin's disease and related entities.

Volume 75, Issue 12, pp. 2434-2437, 06/15/1990
Copyright © 1990 by The American Society of Hematology


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  Copyright © 1990 by American Society of Hematology         Online ISSN: 1528-0020