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Expression of the CD34 gene in vascular endothelial cells
L Fina, HV Molgaard, D Robertson, NJ Bradley, P Monaghan, D Delia, DR Sutherland, MA Baker and MF Greaves
Leukaemia Research Fund Centre, Institute of Cancer Research, London, UK.
All seven of a set of CD34 monoclonal antibodies that recognize epitopes on
an approximately 110 Kd glycoprotein on human hemopoietic progenitor cells
also bind to vascular endothelium. Capillaries of most tissues are CD34
positive, as are umbilical artery and, to a lesser extent, vein, but the
endothelium of most large vessels and the endothelium of placental sinuses
are not. Angioblastoma cells and parafollicular mesenchymal cells in fetal
skin are also CD34 positive, as are some stromal elements. An approximately
110 Kd protein can be identified by Western blot analysis with CD34
antibodies in detergent extracts of freshly isolated umbilical vessel
endothelial cells, and CD34 mRNA is present in cultured umbilical vein
cells as well as other tissues rich in vascular endothelium (breast,
placenta). These data indicate that the binding of CD34 antibodies to
vascular endothelium is to the CD34 gene product, and not to crossreactive
epitopes. Despite the presence of CD34 mRNA in cultured, proliferating
endothelial cells, the latter do not bind CD34 antibodies. In addition,
CD34 antigen cannot be upregulated by growth factors. We conclude that
under these conditions, CD34 protein is downregulated or processed into
another form that is unreactive with CD34 antibodies. Electron microscopy
of umbilical artery, breast, and kidney capillary vessels reveals that in
all three sites, CD34 molecules are concentrated on membrane processes,
many of which interdigitate between adjacent endothelial cells. However,
well-established endothelial cell contacts with tight junctions are CD34
negative. CD34 may function as an adhesion molecule on both endothelial
cells and hematopoietic progenitors.
Volume 75,
Issue 12,
pp. 2417-2426,
06/15/1990
Copyright © 1990 by The American Society of Hematology
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