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Next Article 
Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic
leukemia
I Touw, K Pouwels, T van Agthoven, R van Gurp, L Budel, H Hoogerbrugge, R Delwel, R Goodwin, A Namen and B Lowenberg
Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
We investigated the proliferation-inducing effects of human recombinant
interleukin-7 (IL-7) on acute lymphoblastic leukemia (ALL) cells. It is
shown that IL-7 stimulates DNA synthesis in ALL cells of B-cell precursor
(n = 5) as well as immature T-cell origin (n = 2). Cytogenetic analysis of
the cells of four patients proliferating in IL7- supplemented cultures
established the leukemic descendence of the IL-7- responsive cells.
125I-IL-7 binding experiments with the cells of one patient and with two
ALL cell lines showed the presence of two types of IL-7 receptors: one with
a high affinity (kd 29 to 51 pmol/L) and one with a low affinity (kd 2.3 to
76 nmol/L) for the ligand. We conclude that IL-7 is one of the cytokines
involved in the complex regulation of ALL cell proliferation.
Volume 75,
Issue 11,
pp. 2097-2101,
06/01/1990
Copyright © 1990 by The American Society of Hematology
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