Interleukin-4 induces secretion of CSF for granulocytes and CSF for
macrophages by peripheral blood monocytes
M Wieser, R Bonifer, W Oster, A Lindemann, R Mertelsmann and F Herrmann
Department of Hematology, Johannes Gutenberg University, Mainz, FRG.
T cells are known to interact cooperatively with monocytes to produce
Colony-Stimulating Factors (CSF), although T cell-mediated signals leading
to CSF secretion by monocytes are not completely understood. We have made
use of Northern blot hybridization and specific bioassays to study the
effects of the T cell product interleukin-4 (IL-4) on monocyte CSF
expression. The results suggest a previously unrecognized role of IL-4 as a
CSF inducer since exposure of monocytes to IL-4 resulted in accumulation of
transcripts for granulocyte-CSF (G-CSF) and macrophage-CSF (M-CSF).
Consequently, IL-4-activated monocytes released factors in their culture
supernatants biologically and antigenically indistinguishable from G- and
M-CSF.
Volume 73,
Issue 5,
pp. 1105-1108,
04/01/1989
Copyright © 1989 by The American Society of Hematology
